S008 JAK Inhibitors: A New Frontier in Dermatology
DESCRIPTION
Open admission to eligible categories, no tuition or ticket
Janus kinase (JAK) inhibitors are a new class of medicine in dermatology and are increasingly important due to their unique ability to treat a broad range of inflammatory skin diseases. The application of JAK inhibitors to dermatologic diseases will be presented, including the results of clinical trials and case series. The safety profile of JAK inhibitors will be discussed in detail. The audience for this session will be dermatologists who care for patients with alopecia areata, atopic dermatitis and prurigo nodularis and pruritus, granuloma annulare and sarcoidosis, lichen planus, lupus and dermatomyositis and other CTD, hidradenitis suppurativa, psoriasis, and vitiligo. This activity has been approved by the American Board of Dermatology (ABD) for up to 30 Continuing Certification Program (CCP) Component 2 Self-Assessment points. For more information about CCP, please visit the ABD website at www.abderm.org.
LEARNING OBJECTIVES
Describe a new and important class of medications in dermatology.
Utilize JAK inhibitors for the treatment of alopecia areata, atopic dermatitis, dermatomyositis, granuloma annulare and sarcoidosis, hidradenitis suppurativa, lichen planus, lupus, pruritus, psoriasis, and vitiligo.
Summarize the safety profile of JAK inhibitors and differentiate the safety profile among disease states.
SCHEDULE
2:00 PM
Why JAK Inhibitors are so Broadly Effective
Brett King, MD, PhD, FAAD
2:10 PM
JAK Inhibitors for Vitiligo
Julien Seneschal, MD, PhD
2:25 PM
JAK Inhibitors for Lupus, Dermatomyositis, and SAVI
Ruth Ann Vleugels, MD, MBA, MPH, FAAD
2:40 PM
Q&A
Julien Seneschal, MD, PhD, Ruth Ann Vleugels, MD, MBA, MPH, FAAD
2:50 PM
JAK Inhibitors for Granuloma Annulare and Sarcoidosis
William Damsky, PhD, MD, FAAD
3:05 PM
JAK Inhibitors for Psoriasis
Melinda Gooderham, MD, FAAD
3:20 PM
Q&A
William Damsky, PhD, MD, FAAD, Melinda Gooderham, MD, FAAD
3:30 PM
JAK Inhibitors for Alopecia Areata
Brittany Craiglow, MD, FAAD
3:45 PM
JAK Inhibitors for Lichen Planus and Hidradenitis Suppurativa
Tiffany Mayo, MD, FAAD
4:00 PM
Q&A
Brittany Craiglow, MD, FAAD, Tiffany Mayo, MD, FAAD
4:10 PM
JAK Inhibitors for Atopic Dermatitis, Prurigo Nodularis, and Pruritus
Shawn Kwatra, MD, FAAD
4:30 PM
Understanding the Safety Profile of JAK Inhibitors and Monitoring Patients
Brett King, MD, PhD, FAAD
4:50 PM
Q&A
Brett King, MD, PhD, FAAD, Shawn Kwatra, MD, FAAD
SPEAKERS
Brittany Craiglow, MD, FAAD
William Damsky, PhD, MD, FAAD
Melinda Gooderham, MD, FAAD
Brett King, MD, PhD, FAAD
Shawn Kwatra, MD, FAAD
Tiffany Mayo, MD, FAAD
Julien Seneschal, MD, PhD
Ruth Ann Vleugels, MD, MBA, MPH, FAAD
SPEAKER DISCLOSURES
Brittany Craiglow, MD, FAAD
AbbVie – Consultant (1099 relationship)(Fees), Speaker(Honoraria); Arcutis Biotherapeutics – Consultant (1099 relationship)(Fees), Speaker(Fees); BiologicsMD, Inc. – Consultant (1099 relationship)(Fees); Concert Pharmaceuticals – Consultant(Grants/Research Funding); CorEvitas – Consultant (1099 relationship)(Fees); Dermavant Sciences, Inc. – Advisory Board(Fees); Eli Lilly and Company – Advisory Board(Fees), Consultant(Fees), Speaker(Honoraria); GlaxoSmithKline Immunology – Consultant (1099 relationship)(Fees); Incyte – Advisory Board(Fees); Incyte Corporation – Speaker(Honoraria); Leo Pharma – Advisory Board(Fees); Novartis – Advisory Board(Fees); Pfizer Inc. – Advisory Board(Fees), Consultant(Fees), Investigator(No Compensation Received), Speaker(Honoraria); Regeneron Pharmaceuticals, Inc. – Advisory Board(Fees), Consultant (1099 relationship)(Fees), Speaker(Honoraria); Roivant Sciences – Consultant(Fees); Sanofi Genzyme – Speaker(Honoraria); Sun Pharmaceutical Industries Ltd. – Advisory Board(Fees); Takeda Pharmaceuticals USA Inc – Advisory Board(Fees);
William Damsky, PhD, MD, FAAD
AbbVie – Investigator(Fees); Advanced Cell Diagnostics, Inc. – Investigator(Equipment); Boehringer Ingelheim – Consultant (1099 relationship)(Fees); Bristol – Investigator(Grants/Research Funding); Bristol-Myers Squibb – Investigator(Grants/Research Funding); CSL Behring – Consultant (1099 relationship)(Fees); Eli Lilly and Company – Consultant(Fees); Epiarx Diagnostics – Consultant (1099 relationship)(Fees); Fresenius Kabi – Consultant (1099 relationship)(Fees); Incite – Investigator(Grants/Research Funding); Incyte Corporation – Consultant(Fees), Investigator(Grants/Research Funding); MilliporeSigma – Other(Patent royalties or other compensation for Intellectual Property Rights); Pfizer Inc. – Consultant(Fees), Investigator(Grants/Research Funding); Priovant Therapeutics – Consultant (1099 relationship)(Fees); Sanofi – Consultant (1099 relationship)(Fees); TWi Biote – Consultant (1099 relationship)(Fees); TWi Biotechnology, Inc. – Consultant(Fees), Consultant (1099 relationship)(Fees), Investigator(Fees);
Melinda Gooderham, MD, FAAD
AbbVie – Advisory Board(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); Acelyrin – Investigator(Grants/Research Funding); Amgen – Advisory Board(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); AnaptysBio – Investigator(Grants/Research Funding); Arcutis Biotherapeutics – Advisory Board(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); Aristea Therapeutics – Investigator(Grants/Research Funding); ASLAN Pharmaceuticals – Investigator(Grants/Research Funding); Bausch Health – Consultant(Honoraria), Investigator(Grants/Research Funding); Boehringer Ingelheim – Advisory Board(Honoraria), Consultant(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); Bristol-Myers Squibb – Consultant(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); Cara Therapeutics – Investigator(Grants/Research Funding); Dermavant Sciences – Investigator(Grants/Research Funding); Eli Lilly and Company – Advisory Board(Honoraria), Investigator(Grants/Research Funding), Speaker/Faculty Education(Honoraria); Galderma Laboratories, LP – Investigator(Grants/Research Funding), Speaker(Honoraria); Incyte – Advisory Board(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); Inmagene Biopharmaceuticals – Investigator(Grants/Research Funding); Janssen Pharmaceuticals, Inc – Advisory Board(Honoraria), Consultant(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); Leo Pharma Inc – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Leo Pharma Inc. – Speaker(Honoraria); Meiji Seika Pharma Co., Ltd – Investigator(Grants/Research Funding); Moonlake – Investigator(Grants/Research Funding); Nimbus Therapeutics – Investigator(Grants/Research Funding); Novartis Pharmaceuticals Corp. – Consultant(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); Pfizer Inc. – Advisory Board(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); Regeneron – Advisory Board(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); Reistone Biopharma – Investigator(Grants/Research Funding); Sanofi Genzyme – Consultant(Honoraria), Speaker(Honoraria); Sanofi/Regeneron – Advisory Board(Honoraria); Sun Pharmaceutical Industries Ltd. – Advisory Board(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); Takeda Pharmaceuticals USA Inc – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Tarsus – Investigator(Grants/Research Funding); UCB – Advisory Board(Honoraria), Investigator(Grants/Research Funding), Speaker(Honoraria); Ventyx Biosciences – Investigator(Grants/Research Funding); VYNE Therapeutics – Investigator(Grants/Research Funding);
Brett King, MD, PhD, FAAD
AbbVie – Advisory Board(Honoraria), Speaker(Honoraria); Amgen – Consultant (1099 relationship)(Fees); AnaptysBio – Consultant(Fees), Investigator(Fees); Apogee Therapeutics – Consultant (1099 relationship)(Fees); Aquestive Therapeutics – Consultant (1099 relationship)(Fees); Arena Pharmaceuticals – Consultant(Fees), Investigator(Fees); ASLAN Pharmaceuticals – Consultant (1099 relationship)(Fees), Investigator(Fees); BiologicsMD, Inc. – Consultant(Stock Options); Bristol-Myers Squibb – Advisory Board(Honoraria), Consultant(Fees); Eli Lilly and Company – Consultant(Fees), Investigator(Fees), Speaker(Honoraria); Equillium, Inc. – Consultant (1099 relationship)(Fees); Galderma – Advisory Board(Honoraria); GlaxoSmithKline Immunology – Consultant (1099 relationship)(Fees); Horizon Pharma, Inc. – Consultant(Fees); Incyte Corporation – Advisory Board(Honoraria), Consultant(Fees), Data Safety Monitoring Board(Fees), Speaker(Honoraria); Janssen Pharmaceuticals, Inc – Consultant(Fees); Leo Pharma – Advisory Board(Honoraria); Merck – Consultant (1099 relationship)(Fees); Pfizer Inc. – Advisory Board(Fees), Advisory Board(Honoraria), Consultant(Fees), Investigator(Fees), Speaker(Honoraria); Q32 Bio Inc. – Consultant (1099 relationship)(Fees); Regeneron – Speaker(Honoraria); Sanofi Genzyme – Speaker(Honoraria); Soterios Pharma – Consultant (1099 relationship)(Fees); Sun Pharmaceutical Industries Ltd. – Consultant(Fees), Investigator(Fees); Takeda Pharmaceuticals USA Inc – Advisory Board(Honoraria); TWi Biotechnology, Inc. – Consultant(Fees);
Shawn Kwatra, MD, FAAD
AbbVie – Consultant(Honoraria); Amgen – Advisory Board(Honoraria); Arcutis Biotherapeutics – Advisory Board(Honoraria); Castle Biosciences, Inc – Consultant(Honoraria); Galderma – Investigator(Grants/Research Funding); Galderma USA – Consultant(Honoraria); Incyte Corporation – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Johnson and Johnson – Advisory Board(Honoraria); Leo Pharma Inc – Advisory Board(Honoraria); Novartis – Consultant(Honoraria); Pfizer Inc. – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Regeneron – Advisory Board(Honoraria); Sanofi – Advisory Board(Honoraria), Investigator(Grants/Research Funding);
Tiffany Mayo, MD, FAAD
AbbVie – Consultant (1099 relationship)(Honoraria); Acelyrin – Investigator(Grants/Research Funding); Arcutis Biotherapeutics – Advisory Board(Honoraria); Bristol-Myers Squibb – Advisory Board(Honoraria), Investigator(Grants/Research Funding); ChemoCentryx – Investigator(Grants/Research Funding); Eli Lilly and Company – Investigator(Grants/Research Funding); Galderma – Investigator(Grants/Research Funding); Incyte – Investigator(Grants/Research Funding); Janssen Pharmaceuticals, Inc – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Merck – Advisory Board(Honoraria); Novartis – Advisory Board(Honoraria); Pfizer Inc. – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Procter & Gamble Company – Investigator(Grants/Research Funding); Sanofi – Advisory Board(Honoraria); Takeda Pharmaceuticals USA Inc – Advisory Board(Honoraria); UCB – Advisory Board(Honoraria);
Julien Seneschal, MD, PhD
No financial relationships exist with ineligible companies.
Ruth Ann Vleugels, MD, MBA, MPH, FAAD
AbbVie – Consultant (1099 relationship)(Honoraria); Apogee Therapeutics – Consultant (1099 relationship)(Honoraria); Astra Zeneca – Consultant (1099 relationship)(Honoraria); BMS – Consultant (1099 relationship)(Honoraria); Eli Lilly – Consultant (1099 relationship)(Honoraria); Priovant Therapeutics – Consultant (1099 relationship)(Honoraria);