S007 Atopic Dermatitis
DESCRIPTION
Open admission to eligible categories, no tuition or ticket
This session provides an up-to-date overview about atopic dermatitis, new discoveries, and new therapies. The session is directed towards dermatologists and other health providers who treat adults and/or children with atopic dermatitis. Moderated by Dr. Paller, topics to be reviewed are: Epidemiology and Comorbidities of Atopic Dermatitis (Dr. Drucker); Epidermal Barrier and its Role (Dr. Beck); Immune System and Relevance to Targeted Therapeutics (Dr. Guttman-Yassky); Microbiome and Atopic Dermatitis (Dr. Hata); Topical Therapy (Dr. Eichenfield); Systemic therapy for Adults (Dr. Eric Simpson, MD, MCR); and Systemics for Pediatric Patients (Dr. Paller). Participants are encouraged to bring questions.
LEARNING OBJECTIVES
Recognize the high burden and comorbidities of atopic dermatitis
Identify barrier and immune shifts in atopic dermatitis that form the basis for new therapies
Consider available and emergent therapies in making decisions on atopic dermatitis management
SCHEDULE
2:00 PM
Introduction
Amy S. Paller, MD, FAAD
2:05 PM
Epidemiology and Comorbidities of AD
Aaron Mark Drucker, MD, FAAD
2:25 PM
The Epidermal Barrier and its Role
Lisa A Beck, MD, FAAD
2:50 PM
Immune System Shifts in AD: What is New?
Emma Guttman, MD, PhD, FAAD
3:15 PM
The Microbiome and Atopic Dermatitis
Tissa R. Hata, MD, FAAD
3:35 PM
Topical Therapy
Lawrence F Eichenfield, MD, FAAD
4:00 PM
Systemic therapy for Adults- What’s here/ What’s coming?
Eric Lawrence Simpson, MD, FAAD
4:30 PM
Systemics for Pediatric Patients – Are we there?
Amy S. Paller, MD, FAAD
4:50 PM
Last Chance for Questions and Close
SPEAKERS
Lisa A Beck, MD, FAAD
Aaron Mark Drucker, MD, FAAD
Lawrence F Eichenfield, MD, FAAD
Emma Guttman, MD, PhD, FAAD
Tissa R. Hata, MD, FAAD
Amy S. Paller, MD, FAAD
Eric Lawrence Simpson, MD, FAAD
HANDOUTS
SPEAKER DISCLOSURES
Lisa A Beck, MD, FAAD
AbbVie – Consultant(Fees), Investigator(Grants/Research Funding); Allakos – Advisory Board(Honoraria); AMGEN – Consultant (1099 relationship)(Honoraria); Arcutis Biotherapeutics – Consultant (1099 relationship)(Honoraria); Arena Pharmaceuticals – Advisory Board(Honoraria); ASLAN Pharmaceuticals – Consultant (1099 relationship)(Honoraria); AstraZeneca – Consultant(Fees), Investigator(Grants/Research Funding); Astria Therapeutics – Consultant (1099 relationship)(Honoraria); Belharra Therapeutics – Consultant (1099 relationship)(Honoraria); Celldex – Consultant (1099 relationship)(Honoraria); Dermavent – Consultant (1099 relationship)(Honoraria); Eli Lilly and Company – Consultant(Fees); Escient Pharmaceuticals, Inc – Consultant (1099 relationship)(Honoraria); Galderma Research & Development, LLC – Advisory Board(Honoraria); GlaxoSmithKline Immunology – Consultant (1099 relationship)(Honoraria); Invea Therapeutics – Consultant (1099 relationship)(Honoraria); Janssen Pharmaceuticals, Inc – Advisory Board(Honoraria); LEO Laboratories Ltd (LEO Pharma) – Consultant(Fees); Medtronics – Stockholder(Stock); Merck & Co., Inc – Advisory Board(Honoraria); Nektar Therapeutics – Advisory Board(Honoraria); Novartis – Consultant(Fees); NUMAB Therapeutics AG – Consultant (1099 relationship)(Honoraria); Pfizer Inc. – Consultant(Fees), Investigator(Grants/Research Funding); RAPT Therapeutics – Consultant(Honoraria); Regeneron – Consultant(Fees); Regeneron Pharmaceuticals, Inc. – Investigator(Grants/Research Funding); ResVita Bio, Inc – Consultant (1099 relationship)(Honoraria); Ribon Therapeutics – Consultant(Honoraria); Sanofi – Consultant(Fees), Investigator(Grants/Research Funding); Sitryx Therapeutics – Consultant (1099 relationship)(Honoraria); Stealth Biotherapeutics – Consultant (1099 relationship)(Honoraria); TRex Bio – Consultant (1099 relationship)(Honoraria); Triveni Bio – Consultant (1099 relationship)(Honoraria); UCB Pharma – Consultant (1099 relationship)(Honoraria); Union Therapeutics – Consultant (1099 relationship)(Honoraria); Xencor – Consultant (1099 relationship)(Honoraria);
Aaron Mark Drucker, MD, FAAD
No financial relationships exist with ineligible companies.
Lawrence F Eichenfield, MD, FAAD
AbbVie – Consultant(Honoraria); Abbvie – Investigator(Grants/Research Funding); Almirall – Consultant(Honoraria); Amgen – Consultant (1099 relationship)(Honoraria), Investigator(Grants/Research Funding); Amryt Pharma – Consultant(Honoraria); Apogee Therapeutics – Consultant (1099 relationship)(Honoraria); Arcutis Biotherapeutics – Investigator(Grants/Research Funding); Arcutis, Inc. – Consultant (1099 relationship)(Honoraria); ASLAN Pharmaceuticals – Advisory Board(Honoraria), Consultant (1099 relationship)(Honoraria); Attovia Therapeutics – Consultant (1099 relationship)(Fees); Bristol-Myers Squibb – Consultant(Honoraria); Castle Biosciences, Inc – Investigator(Grants/Research Funding); Dermata Therapeutics – Consultant (1099 relationship)(Stock); Dermavant Sciences, Inc. – Consultant(Honoraria); Eli Lilly – Consultant(Honoraria), Investigator(Grants/Research Funding); Elsevier Inc. – Other(Patent royalties or other compensation for Intellectual Property Rights); Forte Biosciences – Board of Directors(Fees), Board of Directors(Stock Options); Galderma Laboratories, L.P. – Consultant(Honoraria), Investigator(Fees); Incyte Corporation – Consultant(Honoraria); Janssen Pharmaceuticals, Inc – Consultant (1099 relationship)(Honoraria); Kenvue – Consultant (1099 relationship)(Honoraria); Krystal Biotech, Inc – Consultant(Honoraria); LEO Pharma, US – Consultant(Honoraria), Investigator(Fees); Lilly ICOS LLC – Consultant(Honoraria); Novartis – Consultant (1099 relationship)(Honoraria); Ortho Dermatologics – Consultant (1099 relationship)(Honoraria), Investigator(Grants/Research Funding); Pfizer Inc. – Consultant(Honoraria), Investigator(Grants/Research Funding); Sanofi/Regeneron – Consultant(Honoraria), Investigator(Fees); Target RWE – Investigator(Grants/Research Funding); TopMD – Consultant(Stock Options); TRex Bio – Consultant (1099 relationship)(Honoraria); TrialSpark, Inc. – Consultant(Honoraria); UCB – Consultant(Honoraria); Verrica Pharmaceuticals Inc – Board of Directors(Fees), Board of Directors(Stock Options); Wiley-Blackwell – Other(Honoraria);
Emma Guttman, MD, PhD, FAAD
AbbVie – Consultant(Fees), Consultant(Honoraria); Almirall – Consultant(Fees), Consultant(Honoraria); Alumis – Consultant (1099 relationship)(Fees); Amgen – Consultant(Fees), Consultant(Honoraria), Investigator(Grants/Research Funding); AnaptysBio – Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding); Apogee Therapeutics – Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding); Apollo Therapeutics Ltd – Investigator(Grants/Research Funding); Artax Biopharma – Consultant (1099 relationship)(Fees), Consultant (1099 relationship)(Honoraria); ASLAN – Investigator(Grants/Research Funding); AstraZeneca – Consultant (1099 relationship)(Fees), Consultant (1099 relationship)(Honoraria); Boehringer Ingelheim – Consultant(Fees), Consultant(Honoraria), Investigator(Grants/Research Funding); Bristol-Myers Squibb – Advisory Board(Fees), Advisory Board(Honoraria), Consultant(Fees), Consultant(Honoraria); Centrexion Therapeutics Corporation – Consultant (1099 relationship)(Fees); Concert Pharmaceuticals – Investigator(Grants/Research Funding); Connect Biopharma LLC – Consultant(Fees), Consultant(Honoraria); Eli Lilly and Company – Advisory Board(Honoraria), Consultant(Honoraria), Consultant (1099 relationship)(Fees); Enveda Biosciences – Consultant (1099 relationship)(Fees); Escient Pharmaceuticals, Inc – Consultant (1099 relationship)(Fees); Galderma Research & Development, LLC – Advisory Board(Honoraria), Consultant(Honoraria), Consultant (1099 relationship)(Fees); Gate Bioscience – Consultant(Honoraria), Consultant (1099 relationship)(Fees); GlaxoSmithKline – Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding); GlaxoSmithKline Immunology – Consultant (1099 relationship)(Fees); Incyte Corporation – Advisory Board(Honoraria), Consultant(Honoraria), Consultant (1099 relationship)(Fees); Inmagene Biopharmaceuticals – Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding); Janssen Biotech – Consultant (1099 relationship)(Fees); Jasper Therapeutics – Consultant (1099 relationship)(Fees); Kyowa Hakko Kirin Pharma, Inc. – Advisory Board(Honoraria), Consultant(Honoraria), Consultant (1099 relationship)(Fees); Leo Pharma Inc – Advisory Board(Honoraria), Consultant(Fees), Consultant(Honoraria), Investigator(Grants/Research Funding); Matchpoint Therapeutics – Consultant (1099 relationship)(Fees); Merck – Consultant(Fees), Consultant(Honoraria); Nektar Therapeutics – Consultant (1099 relationship)(Fees); Novartis Pharmaceuticals Corporation – Consultant (1099 relationship)(Fees); NUMAB Therapeutics AG – Consultant (1099 relationship)(Fees); Otsuka Pharmaceutical Co., Ltd. – Consultant (1099 relationship)(Fees); Pfizer Inc. – Advisory Board(Honoraria), Consultant(Fees), Investigator(Grants/Research Funding); Pharmaxis Ltd – Consultant (1099 relationship)(Fees); Proteologix US Inc – Consultant (1099 relationship)(Fees); RAPT Therapeutics – Consultant (1099 relationship)(Fees), Consultant (1099 relationship)(Honoraria), Consultant (1099 relationship)(Stock Options), Investigator(Grants/Research Funding); Regeneron – Advisory Board(Honoraria), Consultant(Fees), Consultant(Honoraria); Regeneron Pharmaceuticals, Inc. – Investigator(Grants/Research Funding); RibonTherapeutics, Inc., – Consultant (1099 relationship)(Fees); Sanofi – Advisory Board(Honoraria), Consultant(Fees), Consultant(Honoraria), Investigator(Grants/Research Funding); SATO Pharmaceutical Co., Ltd – Consultant(Fees), Consultant(Honoraria); Schro¨dinger, Inc – Consultant (1099 relationship)(Fees); Sitryx – Consultant (1099 relationship)(Fees); Sun Pharma Advanced Research Company (SPARC) – Consultant (1099 relationship)(Fees); Takeda Pharmaceuticals USA Inc – Consultant (1099 relationship)(Fees); Teva – Consultant (1099 relationship)(Fees); Teva Pharmaceutical Industries Ltd. – Consultant (1099 relationship)(Fees); TRex Bio – Consultant (1099 relationship)(Fees); UCB – Consultant(Fees), Consultant(Honoraria), Investigator(Grants/Research Funding); VRG Therapeutics – Consultant (1099 relationship)(Fees); Xencor – Consultant (1099 relationship)(Fees);
Tissa R. Hata, MD, FAAD
Alumis – Investigator(Grants/Research Funding); Bristol-Myers Squibb – Investigator(Grants/Research Funding); Castle Biosciences, Inc – Investigator(Grants/Research Funding); Eli Lilly and Company – Investigator(Grants/Research Funding); Janssen Pharmaceuticals, Inc – Investigator(Grants/Research Funding); Pfizer Inc. – Investigator(Grants/Research Funding); Unilever – Investigator(Grants/Research Funding);
Amy S. Paller, MD, FAAD
AbbVie – Data Safety Monitoring Board(Honoraria), Investigator(Grants/Research Funding); Abeona Therapeutics – Data Safety Monitoring Board(Honoraria); Arcutis Biotherapeutics – Consultant (1099 relationship)(Honoraria); BioCryst Pharmaceuticals, Inc. – Consultant (1099 relationship)(Honoraria), Data Safety Monitoring Board(Honoraria); BioMendics, LLC – Investigator(Grants/Research Funding); Boehringer Ingelheim – Consultant(Honoraria); Castle Creek Pharmaceuticals – Consultant (1099 relationship)(Honoraria); Chiesi Farmaceutici – Consultant (1099 relationship)(Honoraria); Daiichi Sankyo – Data Safety Monitoring Board(Honoraria); Dermavant Sciences, Inc. – Investigator(Grants/Research Funding); Eli Lilly – Consultant (1099 relationship)(Honoraria), Investigator(Grants/Research Funding); Galderma – Data Safety Monitoring Board(Honoraria); Incyte Corporation – Investigator(Grants/Research Funding); Johnson & Johnson Innovative Medicine – Consultant (1099 relationship)(Honoraria), Investigator(Grants/Research Funding); Krystal Biotech, Inc – Consultant(Honoraria); L'Oréal France – Consultant (1099 relationship)(Honoraria); Leo Pharma Inc – Consultant(Honoraria); MoonLake Immunotherapeutics – Consultant (1099 relationship)(Honoraria); Pelthos Therapeutics – Consultant (1099 relationship)(Honoraria); Quoin Pharmaceuticals Ltd – Consultant (1099 relationship)(Honoraria); Regeneron – Consultant(Honoraria), Investigator(Grants/Research Funding); Sanofi Genzyme – Consultant(Honoraria); UCB – Investigator(Grants/Research Funding);
Eric Lawrence Simpson, MD, FAAD
AbbVie – Consultant(Fees), Investigator(Grants/Research Funding); Acrotech Biopharma Inc – Investigator(Grants/Research Funding); Amgen – Consultant(Fees), Investigator(Grants/Research Funding); Arcutis Biotherapeutics – Consultant(Fees); Arcutis, Inc. – Investigator(Grants/Research Funding); Areteia Therapeutics – Consultant (1099 relationship)(Fees); ASLAN – Consultant(Fees); ASLAN Pharmaceuticals – Investigator(Grants/Research Funding); Astria Therapeutics – Consultant (1099 relationship)(Fees); Bristol-Myers Squibb – Consultant(Fees); Castle Biosciences – Investigator(Grants/Research Funding); CorEvitas – Consultant(Fees), Investigator(Grants/Research Funding); Corvus Pharmaceuticals – Consultant (1099 relationship)(Fees); Demira – Consultant(Fees); Dermavant – Investigator(Grants/Research Funding); Dermavant Sciences, Inc. – Investigator(Grants/Research Funding); Dermira – Investigator(Grants/Research Funding); Eli Lilly and Company – Consultant(Fees), Investigator(Grants/Research Funding); Evelo Biosciences, Inc. – Consultant(Fees); FIDE – Speaker/Faculty Education(Fees); Forte Biosciences – Consultant(Fees); Galderma Laboratories, LP – Consultant (1099 relationship)(Fees); Gilead Sciences, Inc – Consultant (1099 relationship)(Fees); GlaxoSmithKline – Consultant(Fees); Impetus Healthcare – Consultant (1099 relationship)(Fees); Incyte Corporation – Consultant(Fees), Investigator(Grants/Research Funding); Innovaderm Research Inc. – Consultant (1099 relationship)(Fees); Janssen Research & Development, LLC – Consultant(Fees); Johnson & Johnson Pharmaceutical Research & Development – Consultant(Fees); Kymab – Investigator(Grants/Research Funding); Kyowa Hakko Kirin Pharma, Inc. – Consultant(Fees), Investigator(Grants/Research Funding); Leo Pharma Inc. – Consultant(Fees), Investigator(Grants/Research Funding); Med Learning Group – Consultant(Fees); Merck – Advisory Board(Fees); National Jewish Health – Investigator(Grants/Research Funding); Novartis – Investigator(Grants/Research Funding); NUMAB Therapeutics AG – Consultant (1099 relationship)(Fees); Pfizer Inc. – Consultant(Fees), Investigator(Grants/Research Funding); Physicians World LLC – Consultant(Fees); Prime Education – Speaker/Faculty Education(Honoraria); Recludix Pharma – Consultant (1099 relationship)(Fees); Regeneron – Consultant(Fees), Investigator(Grants/Research Funding); Roche Products Ltd – Consultant (1099 relationship)(Fees); Roivant Sciences – Consultant(Fees), Consultant (1099 relationship)(Fees); Sanofi – Investigator(Grants/Research Funding); Sanofi Genzyme – Consultant(Fees), Investigator(Grants/Research Funding); SITRYX – Consultant (1099 relationship)(Fees); Target RWE – Investigator(Grants/Research Funding); Tioga Pharmaceuticals, Inc. – Investigator(Grants/Research Funding); Trevi Therapeutics – Consultant(Fees); Valeant Pharmaceuticals International – Consultant(Fees); Vanda Pharmaceuticals Inc. – Investigator(Grants/Research Funding); Veriskin – Investigator(Grants/Research Funding); Vindico Medical Education – Speaker/Faculty Education(Honoraria); WebMD – Consultant(Fees);