S040 Inflammatory Skin Diseases: The Translational Revolution
DESCRIPTION
Open admission to eligible categories, no tuition or ticket
In the past decade we experienced a revolution in the mechanistic understanding of inflammatory skin diseases. This translational revolution started with psoriasis, and is now extending to many other common inflammatory skin diseases, and particularly atopic dermatitis, alopecia areata, vitiligo, hidradenitis suppurativa, pustular psoriasis, and acne/rosacea. These advances are now translating to rapid development and testing in early and late stage clinical trials of more narrow, targeted treatments for these diseases, that are safer for long-term disease control than older, primarily immune suppressant treatments. In this symposium we will address both the increased understanding and the novel therapeutic developments for common inflammatory skin diseases that we see in daily practice, that ultimately will improve patient care.
LEARNING OBJECTIVES
Identify the immune axes involved in common inflammatory skin diseases.
Recognize how different treatment approaches work in various inflammatory diseases.
Describe the commonalities between various inflammatory skin diseases and how new treatments may commonly treat them. Apply new knowledge to improving future treatments.
SCHEDULE
9:00 PM
Introduction
Emma Guttman, MD, PhD, FAAD
9:05 PM
The translational revolution in inflammatory skin diseases
Mark Lebwohl, MD, FAAD
9:30 PM
Psoriasis: a model disease for therapeutic targeting
Bruce Elliot Strober, MD, PhD, FAAD
9:55 PM
Atopic Dermatitis: pushing the boundaries of treatment efficacy
Emma Guttman, MD, PhD, FAAD
10:20 PM
Alopecia areata: the evolving therapeutic revolution
Natasha Atanaskova Mesinkovska, PhD, MD, FAAD
10:45 PM
Vitiligo: An unfolding story
John Harris, MD, PhD, FAAD
11:10 PM
Hidradenitis Suppurativa: New developments
James G. Krueger, MD, PhD, FAAD
11:35 PM
New advances in Rosacea and Seborrheic Dermatitis
Benjamin Ungar, MD, FAAD
11:55 PM
Conclusion
James G. Krueger, MD, PhD, FAAD
SPEAKERS
Emma Guttman, MD, PhD, FAAD
John Harris, MD, PhD, FAAD
James G. Krueger, MD, PhD, FAAD
Mark Lebwohl, MD, FAAD
Natasha Atanaskova Mesinkovska, PhD, MD, FAAD
Bruce Elliot Strober, MD, PhD, FAAD
Benjamin Ungar, MD, FAAD
HANDOUTS
SPEAKER DISCLOSURES
Emma Guttman, MD, PhD, FAAD
AbbVie – Consultant(Fees), Consultant(Honoraria); Almirall – Consultant(Fees), Consultant(Honoraria); Amgen – Consultant(Fees), Consultant(Honoraria), Investigator(Grants/Research Funding); AnaptysBio – Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding); Apogee Therapeutics – Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding); Apollo Therapeutics Ltd – Investigator(Grants/Research Funding); Artax Biopharma – Consultant (1099 relationship)(Fees), Consultant (1099 relationship)(Honoraria); ASLAN – Investigator(Grants/Research Funding); AstraZeneca – Consultant (1099 relationship)(Fees), Consultant (1099 relationship)(Honoraria); Boehringer Ingelheim – Consultant(Fees), Consultant(Honoraria), Investigator(Grants/Research Funding); Bristol-Myers Squibb – Advisory Board(Fees), Advisory Board(Honoraria), Consultant(Fees), Consultant(Honoraria); Cara Therapeutics – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Centrexion Therapeutics Corporation – Consultant (1099 relationship)(Fees); Concert Pharmaceuticals – Investigator(Grants/Research Funding); Connect Biopharma LLC – Consultant(Fees), Consultant(Honoraria); Eli Lilly and Company – Advisory Board(Honoraria), Consultant(Honoraria), Consultant (1099 relationship)(Fees); Enveda Biosciences – Consultant (1099 relationship)(Fees); Escient Pharmaceuticals, Inc – Consultant (1099 relationship)(Fees); Fairmount Funds Management LLC – Consultant (1099 relationship)(Fees); Forest Laboratories – Consultant (1099 relationship)(Fees); Galderma Research & Development, LLC – Advisory Board(Honoraria), Consultant(Honoraria), Consultant (1099 relationship)(Fees); Gate Bioscience – Consultant(Honoraria), Consultant (1099 relationship)(Fees); GlaxoSmithKline – Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding); GlaxoSmithKline Immunology – Consultant (1099 relationship)(Fees); Google Ventures – Consultant (1099 relationship)(Fees); Horizon Therapeutics USA, Inc – Consultant (1099 relationship)(Fees); Incyte Corporation – Advisory Board(Honoraria), Consultant(Honoraria), Consultant (1099 relationship)(Fees); janssen – Consultant(Honoraria); Janssen Biotech – Consultant (1099 relationship)(Fees); Janssen Pharmaceuticals, Inc – Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding); Japan Tobacco Inc. – Consultant (1099 relationship)(Fees); Jasper Therapeutics – Consultant (1099 relationship)(Fees); JT Central Pharmaceutical Research Institute – Consultant (1099 relationship)(Fees); Kyowa Hakko Kirin Pharma, Inc. – Advisory Board(Honoraria), Consultant(Honoraria), Consultant (1099 relationship)(Fees), Investigator(Grants/Research Funding); Leo Pharma Inc – Advisory Board(Honoraria), Consultant(Fees), Consultant(Honoraria), Investigator(Grants/Research Funding); Merck – Consultant(Fees), Consultant(Honoraria); Nektar Therapeutics – Consultant (1099 relationship)(Fees); Novartis Pharmaceuticals Corporation – Consultant (1099 relationship)(Fees); NUMAB Therapeutics AG – Consultant (1099 relationship)(Fees); OrbiMed Advisors LLC – Consultant (1099 relationship)(Fees); Otsuka Pharmaceutical Co., Ltd. – Consultant (1099 relationship)(Fees); Pfizer Inc. – Advisory Board(Honoraria), Consultant(Fees), Consultant(Honoraria), Investigator(Grants/Research Funding); Pharmaxis Ltd – Consultant (1099 relationship)(Fees); Pioneering Medicine VII, Inc – Consultant (1099 relationship)(Fees); Pioneering Medicines – Consultant (1099 relationship)(Fees); Proteologix US Inc – Consultant (1099 relationship)(Fees); RAPT Therapeutics – Consultant (1099 relationship)(Fees), Consultant (1099 relationship)(Honoraria), Investigator(Grants/Research Funding), Stockholder(Stock Options); Regeneron – Advisory Board(Honoraria), Consultant(Fees), Consultant(Honoraria); Regeneron Pharmaceuticals, Inc. – Investigator(Grants/Research Funding); RibonTherapeutics, Inc., – Consultant (1099 relationship)(Fees); Sanofi – Advisory Board(Honoraria), Consultant(Fees), Consultant(Honoraria), Investigator(Grants/Research Funding); SATO Pharmaceutical Co., Ltd – Consultant(Fees), Consultant(Honoraria); Schro¨dinger, Inc – Consultant (1099 relationship)(Fees); Sun Pharma Advanced Research Company (SPARC) – Consultant (1099 relationship)(Fees); Teva – Consultant (1099 relationship)(Fees); Teva Pharmaceutical Industries Ltd. – Consultant (1099 relationship)(Fees); UCB – Consultant(Fees), Consultant(Honoraria), Investigator(Grants/Research Funding);
John Harris, MD, PhD, FAAD
AbbVie – Consultant(Honoraria), Investigator(Grants/Research Funding); Aclaris Therapeutics Inc. – Investigator(Grants/Research Funding); Aclaris Therapeutics, Inc. – Consultant(Fees); Aldena Therapeutics – Consultant(Fees), Founder(Stock); Almirall – Consultant(Fees); AnaptysBio – Consultant(Fees); Avita – Consultant(Fees); BiologicsMD, Inc. – Consultant(Honoraria); Celgene Corporation – Investigator(Grants/Research Funding); Dermavant Sciences – Consultant(Fees), Investigator(Grants/Research Funding); Dermira – Investigator(Grants/Research Funding); Genzyme Corporation – Consultant(Honoraria), Investigator(Grants/Research Funding); Granular Therapeutics – Consultant(Fees); Incyte Corporation – Investigator(Grants/Research Funding); Klirna Biotech, Inc. – Founder(Stock); Klirna Therapeutics – Founder(Stock); Leo Pharma Inc – Investigator(Grants/Research Funding); Nira Biosciences, Inc. – Consultant(Fees), Founder(Stock); Pandion Therapeutics – Consultant(Fees); Pfizer Inc. – Consultant(Honoraria), Investigator(Grants/Research Funding); Platelet BioGenesis, Inc. – Consultant(Fees); Rheos Medicines – Consultant(Honoraria), Investigator(Grants/Research Funding); Stiefel a GSK company – Investigator(Grants/Research Funding); Sun Pharmaceutical Industries Ltd. – Consultant(Honoraria); TeVido Biodevices, LLC – Advisory Board(Stock Options), Investigator(Grants/Research Funding), Stockholder(Stock); Villaris Therapeutics, Inc – Founder(Stock), Investigator(Grants/Research Funding); Vimela – Consultant(Honoraria), Stockholder(Stock); Vividion Therapeutics – Consultant (1099 relationship)(Fees);
James G. Krueger, MD, PhD, FAAD
AbbVie – Consultant(Honoraria), Investigator(Grants/Research Funding); Aclaris Therapeutics Inc. – Consultant(Honoraria); Akros Pharma, Inc. – Investigator(Grants/Research Funding); Allergan, Inc. – Consultant(Honoraria), Investigator(Grants/Research Funding); Almirall – Consultant(Honoraria); Amgen – Consultant(Honoraria), Investigator(Grants/Research Funding); Arena Pharmaceuticals – Consultant(Honoraria); Aristea Therapeutics – Consultant(Honoraria); Artax Biopharma – Consultant(Honoraria); Asana Biosciences, LLC – Consultant(Honoraria); Aurigene Discovery Technologies, Inc. – Consultant(Honoraria); Avillion – Investigator(Grants/Research Funding); Biogen – Consultant(Honoraria), Investigator(Grants/Research Funding); Boehringer Ingelheim – Consultant(Honoraria), Investigator(Grants/Research Funding); Botanix Pharmaceuticals – Investigator(Grants/Research Funding); Bristol-Myers Squibb – Consultant(Honoraria), Investigator(Grants/Research Funding); Eli Lilly and Company – Consultant(Honoraria), Investigator(Grants/Research Funding); Escalier – Consultant(Honoraria); Exicure – Investigator(Grants/Research Funding); Galapagos NV – Consultant(Honoraria); Incyte Corporation – Investigator(Grants/Research Funding); Innovaderm Research Inc. – Investigator(Grants/Research Funding); Janssen Pharmaceuticals, Inc – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Kyowa Kirin – Consultant(Honoraria), Investigator(Grants/Research Funding); MoonLake Immunotherapeutics – Consultant(Honoraria); Nimbus Therapeutics – Consultant(Honoraria), Investigator(Grants/Research Funding); Novan – Investigator(Grants/Research Funding); Novartis – Investigator(Grants/Research Funding); Novartis Pharmaceuticals Corp. – Consultant(Honoraria); Parexel – Investigator(Grants/Research Funding); Pfizer Inc. – Consultant(Honoraria), Investigator(Grants/Research Funding); Regeneron – Investigator(Grants/Research Funding); Sanofi US Services – Consultant(Honoraria); Sienna Biopharmaceuticals – Consultant(Honoraria); Sun Pharmaceutical Industries Ltd. – Consultant(Honoraria); Target-Derm – Consultant(Honoraria); UCB – Consultant(Honoraria), Investigator(Grants/Research Funding); Valeant Pharmaceuticals North America LLC – Consultant(Honoraria); Ventyx Biosciences – Consultant(Honoraria); Vitae Pharmaceuticals – Investigator(Grants/Research Funding);
Mark Lebwohl, MD, FAAD
AbbVie – Investigator(Grants/Research Funding); Almirall – Consultant(Honoraria); AltruBio Inc. – Consultant(Honoraria); Apogee Therapeutics – Consultant(Honoraria); Arcutis, Inc. – Consultant(Honoraria), Investigator(Grants/Research Funding); AstraZeneca – Consultant (1099 relationship)(Honoraria); Atomwise – Consultant(Honoraria); Avotres, Inc. – Consultant(Honoraria), Investigator(Grants/Research Funding); Boehringer Ingelheim – Consultant(Honoraria), Investigator(Grants/Research Funding); Bristol-Myers Squibb – Consultant(Honoraria); Cara Therapeutics – Investigator(Grants/Research Funding); Castle Biosciences, Inc – Consultant(Honoraria); Celltrion – Consultant(Honoraria); Clexio Biosciences, Ltd – Investigator(Grants/Research Funding); CoreEvitas, LLC – Consultant(Honoraria); Dermavant Sciences – Consultant(Honoraria), Investigator(Grants/Research Funding); Dermsquared – Consultant (1099 relationship)(Honoraria); Eli Lilly and Company – Investigator(Grants/Research Funding); Evommune, Inc. – Consultant(Honoraria); Facilitation of International Dermatology Education – Consultant(Honoraria); Forte Biosciences – Consultant(Honoraria); Galderma – Consultant(Honoraria); Genentech, Inc. – Consultant(Honoraria); Incyte Corporation – Consultant(Honoraria), Investigator(Grants/Research Funding); Inozyme Pharma – Investigator(Grants/Research Funding); Janssen Research & Development, LLC – Investigator(Grants/Research Funding); Leo Pharma A/S – Consultant(Honoraria); Meiji Seika Pharma Co., Ltd – Consultant(Honoraria); Mindera – Consultant(Honoraria); New York College of Podiatric Medicine – Speaker/Faculty Education(Honoraria); Ortho Dermatologics – Investigator(Grants/Research Funding); Pfizer Inc. – Consultant(Honoraria), Investigator(Grants/Research Funding); Sanofi/Regeneron – Consultant (1099 relationship)(Honoraria), Investigator(Grants/Research Funding); Seanergy Maritime Holdings Corp. – Consultant(Honoraria); Strata Skin Sciences – Consultant(Honoraria); Takeda Pharmaceuticals USA Inc – Consultant (1099 relationship)(Honoraria); Trevi Therapeutics – Consultant(Honoraria); UCB – Investigator(Grants/Research Funding); Verrica Pharmaceuticals Inc – Consultant(Honoraria);
Natasha Atanaskova Mesinkovska, PhD, MD, FAAD
AbbVie – Investigator(No Compensation Received); Arcutis, Inc. – Investigator(No Compensation Received); Arena Pharmaceuticals – Advisory Board(Honoraria), Investigator(No Compensation Received); Concert Pharmaceuticals – Advisory Board(Honoraria); Eli Lilly – Speaker(Honoraria); Kyowa Hakko Kirin Pharma, Inc. – Investigator(No Compensation Received); La Roche-Posay Laboratorie Pharmaceutique – Advisory Board(Honoraria); Lilly ICOS LLC – Advisory Board(Honoraria), Investigator(No Compensation Received); Merz Aesthetics – Investigator(Grants/Research Funding); Nutrafol – Advisory Board(Honoraria); Pfizer Inc. – Advisory Board(Honoraria), Investigator(Grants/Research Funding);
Bruce Elliot Strober, MD, PhD, FAAD
AbbVie – Advisory Board(Honoraria), Consultant(Honoraria), Speaker(Honoraria); Alumis – Consultant(Fees); Amgen – Consultant (1099 relationship)(Fees); Arcutis, Inc. – Consultant(Fees), Speaker(Honoraria); Boehringer Ingelheim – Consultant(Honoraria); Bristol Myers Squibb – Speaker(Honoraria); Bristol-Myers Squibb – Advisory Board(Honoraria), Consultant(Fees); Connect Biopharma LLC – Stockholder(Other Financial Benefit); CoreEvitas, LLC – Advisory Board(Honoraria), Investigator(Fees); Dermavant Sciences, Inc. – Consultant(Fees), Speaker(Honoraria); Eli Lilly and Company – Advisory Board(Honoraria), Consultant(Honoraria), Speaker(Honoraria); Janssen Biotech – Speaker(Honoraria); Janssen-Ortho Inc. – Advisory Board(Honoraria), Consultant(Honoraria); Leo Pharma Inc – Advisory Board(Honoraria), Consultant(Honoraria); Meiji Seika Pharma Co., Ltd – Consultant(Fees); Mindera – Stockholder(Other Financial Benefit); Novartis Pharmaceuticals Corp. – Advisory Board(Honoraria), Consultant(Honoraria); Oruka Therapeutics – Advisory Board(Honoraria); Pfizer Inc. – Consultant(Honoraria); Sanofi/Regeneron – Advisory Board(Honoraria), Consultant(Honoraria), Speaker(Honoraria); UCB – Advisory Board(Honoraria), Consultant(Fees), Speaker(Honoraria); Union Therapeutics – Consultant(Fees);
Benjamin Ungar, MD, FAAD
Arcutis Biotherapeutics – Advisory Board(Honoraria); Bristol-Myers Squibb – Advisory Board(Honoraria); Castle Biosciences – Advisory Board(Honoraria); Fresenius Kabi – Advisory Board(Honoraria); Galderma – Advisory Board(Honoraria); Incyte Corporation – Investigator(Grants/Research Funding); Pfizer Inc. – Advisory Board(Honoraria), Investigator(Grants/Research Funding); Primus Pharmaceuticals – Advisory Board(Honoraria); RAPT Therapeutics – Investigator(Grants/Research Funding); Sanofi – Advisory Board(Honoraria); Target-Derm – Advisory Board(Honoraria); UCB – Advisory Board(Honoraria);